Gif Central boasts hundreds of funny animated gifs. Only the best of the best make it onto this site, with most of them having an accompanying source. No tumblr-esque one-second-long disappointments. No obscure titles or descriptions.
This is an animated reaction gif of a little girl in the backseat of a car flipping the bird / sticking her middle finger up. This is from the movie The Hangover (2009). I believe that it was directed at Alan (Zach Galifianakis).