Gif Central boasts hundreds of funny animated gifs. Only the best of the best make it onto this site, with most of them having an accompanying source. No tumblr-esque one-second-long disappointments. No obscure titles or descriptions.
This is animated gif of Jimmy McNulty kicking his desk in anger. This is a scene from the popular HBO TV show The Wire, which ran between 2002 and 2008. This can be used as a reaction gif for obvious reasons.